Measurement of Macrophage Cellular Procoagulant Activity
نویسندگان
چکیده
منابع مشابه
Cellular mechanisms of abscess formation: macrophage procoagulant activity and major histocompatibility complex recognition.
BACKGROUND Macrophage procoagulant activity (PCA) has been proposed as a key mediator of abscess formation. Experimentally, transient systemic bacterial infection lead to increased numbers of intraabdominal abscesses after a subsequent episode of peritonitis. We tested the hypothesis that these events were regulated by classic major histocompatibility complex (MHC)-restricted antigen processing...
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The metastatic process is a complex sequence of steps that may involve coagulation and the presence of fibrin. F1 (low incidence of lung colonization) and F10 (high incidence of lung colonization) variants of the B16 mouse melanoma were used to examine the relationship between the level of cellular procoagulant activity and their metastatic potential. Cell suspensions were prepared from culture...
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To explore the induction of monocyte/macrophage procoagulant activity in autoimmune disease, the BXSB murine model of systemic lupus erythematosus was studied. Splenic macrophage procoagulant activity rose coincident with age and the development of glomerulonephritis from 38 +/- 6 mU/10(6) macrophages at 1 mo to a maximum of 29,000 +/- 15,000 mU at 4 mo. Macrophages from 1-mo-old mice could be ...
متن کاملLymphocyte cooperation is required for amplification of macrophage procoagulant activity
Murine splenic lymphoid cells have been shown to possess basal procoagulant activity. This activity was localized to most macrophages by assay of cell populations, as well as by a direct plaque assay that permitted identification of expressed procoagulant activity of individual viable cells as well as content. Both content and viable expression of procoagulant activity was markedly increased by...
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The biological diversity of the immune system is reflected in the variety of immune effector systems and mediation pathways that have emerged. Among the least recognized involve the hemostatic pathways. The possibility of cellular and molecular linkages between two host defense mechanisms, the hemostatic and immune systems, has long been suggested, but has yet to be satisfactorily delineated. T...
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ژورنال
عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis
سال: 1985
ISSN: 1424-8840,1424-8832
DOI: 10.1159/000215130